Volume 8, Issue 5, September 2020, Page: 61-65
Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia
Fumio Bessho, Department of Education of General Medicine, Faculty of Health Sciences, Nihon Institute of Medical Science, Saitama, Japan
Masako Tanimura, Department of Pediatrics, Kyorin University School of Medicine, Tokyo, Japan
Received: Aug. 28, 2020;       Accepted: Sep. 11, 2020;       Published: Sep. 23, 2020
DOI: 10.11648/j.ejpm.20200805.11      View  67      Downloads  29
Abstract
We herein determined the effects of parental smoking on occurrence of childhood acute leukemia using the large volume of data accumulated in the Japan Children's Cancer Registry. Information on the smoking statuses of fathers was available for 4,802 acute leukemia cases diagnosed between 1985 and 2006 and that of mothers was available for 5,536 cases diagnosed between 1978 and 2006. We compared the smoking rates of parents whose children were diagnosed with leukemia with a control group of parents whose children were diagnosed with benign tumors or cancer-related diseases. The smoking rate of fathers was significantly larger than the control. The odds ratios were 1.284 for 1-9 cigarettes/day (c/d) before conception (p=0.127), 1.265 for 10-19 c/d (p=0.029), and 1.345 for more than 20 c/d (p=0.000). A logistic regression analysis controlling for sex, birth weight, paternal age at birth, and maternal smoking showed that the smoking rate of fathers whose children had acute leukemia was still significantly higher (OR 1.012, p=0.004). The difference of the smoking rate between mothers whose children had acute leukemia and the control mothers was not significant (OR 1.161, p=0.447).
Keywords
Childhood Acute Leukemia, Parental Smoking, Sperm, Fetus
To cite this article
Fumio Bessho, Masako Tanimura, Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia, European Journal of Preventive Medicine. Vol. 8, No. 5, 2020, pp. 61-65. doi: 10.11648/j.ejpm.20200805.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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