Volume 7, Issue 3, May 2019, Page: 57-64
Association of Microalbuminuria with Abnormal Left Ventricular Geometry Patterns in Nigerian Normotensive Type 2 Diabetic Patients
Taiwo Tolulope Shogade, Department of Internal Medicine, University of Uyo Teaching Hospital, Uyo, Nigeria
Ime Okon Essien, Department of Internal Medicine, University of Uyo Teaching Hospital, Uyo, Nigeria
Udeme Ekpenyong Ekrikpo, Department of Internal Medicine, University of Uyo Teaching Hospital, Uyo, Nigeria
Idongesit Odudu Umoh, Department of Internal Medicine, University of Uyo Teaching Hospital, Uyo, Nigeria
Clement Tom Utin, Department of Echocardiography, Cleno Health Ultrasound Institute, Uyo, Nigeria
Akpabio Akanimo Akpabio, Department of Internal Medicine, University of Uyo Teaching Hospital, Uyo, Nigeria
Joseph John Andy, Department of Internal Medicine, University of Uyo Teaching Hospital, Uyo, Nigeria
Received: Mar. 25, 2019;       Accepted: Jul. 3, 2019;       Published: Jul. 17, 2019
DOI: 10.11648/j.ejpm.20190703.11      View  123      Downloads  9
Abstract
To compare left ventricular (LV) geometry patterns among normotensive type 2 diabetics (NT2DM) with normoalbuminuria, NT2DM with microalbuminuria and healthy controls. A cross-sectional study conducted at the medical outpatient department of a Teaching Hospital from January 2013 to March 2014. Sixty-three normoalbuminuric NT2DM, 71 microalbuminuric NT2DM and fifty-nine healthy controls were recruited. Microalbuminuria was tested for using Micral test strips (Roche, Germany). Trans-thoracic echocardiography was carried out on all subjects. Relative wall thickness (RWT), left ventricular mass index (LVMI) and LV geometry patterns were compared among the three groups. The three groups were age and sex-matched and appropriate statistical tests were used for comparisons with p<0.05. The proportions of abnormal LV geometry (33.3% vs 71.4% vs 84.5%), LVMI and RWT showed a significant stepwise increase from healthy controls through normoalbuminuric NT2DM and to microalbuminuric NT2DM (all p<0.01). Concentric remodeling (CR) was the commonest pattern among the three groups. Left ventricular mass index and RWT correlated significantly with duration of DM and body mass index (all p< 0.01). Microalbuminuria showed a strong direct association with abnormal LV geometry (OR 3.27, 95% CI 1.63-6.57, p<0.01) while duration of DM was found to be an independent predictor of LV geometry remodeling (OR 1.23, 95% CI 1.02-1.49, p = 0.03) among normotensive diabetics. Although CR was the commonest pattern across the three patient groups, those with microalbuminuria had the highest proportion and risk of LV remodeling. Early screening and prompt treatment of microalbuminuria in NT2DM is hereby recommended.
Keywords
Diabetes Mellitus, Left Ventricular Geometry, Microalbuminuria, Normotensive
To cite this article
Taiwo Tolulope Shogade, Ime Okon Essien, Udeme Ekpenyong Ekrikpo, Idongesit Odudu Umoh, Clement Tom Utin, Akpabio Akanimo Akpabio, Joseph John Andy, Association of Microalbuminuria with Abnormal Left Ventricular Geometry Patterns in Nigerian Normotensive Type 2 Diabetic Patients, European Journal of Preventive Medicine. Vol. 7, No. 3, 2019, pp. 57-64. doi: 10.11648/j.ejpm.20190703.11
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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