Volume 4, Issue 3, May 2016, Page: 79-84
Diagnostic Value of Homocysteine, Cystatin C and Lipid Indices in Assessment of Cardiovascular Risk Status of Patients with Diabetes Type 2
Brown Holy, Dept. of Medical Laboratory Science, Rivers State University of Science and Technology, Npkolu, Port Harcourt, Nigeria
Joshua Marcella Tari, Dept. of Medical Laboratory Science, Rivers State University of Science and Technology, Npkolu, Port Harcourt, Nigeria
Received: Apr. 7, 2016;       Accepted: Apr. 19, 2016;       Published: May 3, 2016
DOI: 10.11648/j.ejpm.20160403.15      View  2738      Downloads  81
Diabetes mellitus (DM) is characterized by hyperglycaemia and glycosuria due to defects in insulin secretion from the Islets of Langerhans and associated with cardiovascular disease (CVD). The imperativeness to assess effectiveness of various cardiovascular risk tools is critical with increasing rate of people with diabetes type 2. Study was aimed at the assessment and evaluation of the diagnostic relevance of homocysteine, Cystatin C, cardiovascular risk indices in the risk profile of cardiovascular diseases in Type 2 diabetes mellitus patients. A total of 165 patients were involved in the study, of which 100 were diabetic (test) and 65 non-diabetics (control). The diabetic subjects were those whose glycated haemoglobin (HbA1C) levels were ≥ 6.5%. HbA1C was estimated quantitatively by immunochemical method, Homocysteine (Hcy), Cystatin C, Lipoprotein (a) (Lp (a) were measured by Enzyme Linked Immunosorbent assay (ELISA) method; Glucose oxidase method was used for the determination of fasting plasma glucose (FBS). The results showed elevated serum homocysteine (Hcy), Lp (a) among the diabetics as compared to the non-diabetic subjects (p<0.05). The diabetic subjects also depicted higher Cystatin C (Cys C) levels, in the diabetic type 2 patients compared to the non-diabetic patients. The lipid profile levels in the diabetic subjects showed higher mean values of total cholesterol and triglycerides, (p < 0.05) as compared with the non-diabetic. The percentage risk predictive values of cardiovascular disease in the diabetic sub-population with these risk indices showed Hcy with a sensitivity of 96%, specificity of 96.9% and an accuracy of 96.5% as compared to Cys C with a sensitivity of 95%, specificity of 96.9%, accuracy of 95.9% also compared with that of Lp (a) with a sensitivity of 91%, specificity of 100% and an accuracy of 95.5%. The level of accuracy of Hcy, Cys C and then Lp (a) amongst other indices showed that these diagnostic tools could provide better platform in cardiovascular risk profiling of T2DM patients and should be encouraged.
Diabetes, Cardiovascular, Risk, Cystatin C, Homocysteine, Lipids
To cite this article
Brown Holy, Joshua Marcella Tari, Diagnostic Value of Homocysteine, Cystatin C and Lipid Indices in Assessment of Cardiovascular Risk Status of Patients with Diabetes Type 2, European Journal of Preventive Medicine. Vol. 4, No. 3, 2016, pp. 79-84. doi: 10.11648/j.ejpm.20160403.15
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